Ultrasound imaging of the lactating breast: methodology and application
© Geddes; licensee BioMed Central Ltd. 2009
Received: 07 October 2008
Accepted: 29 April 2009
Published: 29 April 2009
Ultrasound imaging has been used extensively to detect abnormalities of the non-lactating breast. In contrast, the use of ultrasound for the investigation of pathology of the lactating breast is limited. Recent studies have re-examined the anatomy of the lactating breast highlighting features unique to this phase of breast development. These features should be taken into consideration along with knowledge of common lactation pathologies in order to make an accurate diagnosis when examining the lactating breast. Scanning techniques and ultrasound appearances of the normal lactating breast will be contrasted to those of the non-lactating breast. In addition ultrasound characteristics of common pathologies encountered during lactation will be described.
The lactating breast produces milk of a complex composition that is tailored for the optimal growth and development of the term infant , yet the knowledge regarding pathology and treatment of the lactating breast is limited compared to that of the non-lactating breast. Ultrasound imaging provides a non-invasive method of investigating the breast during lactation and this paper will review ultrasound techniques used during lactation along with normal and abnormal appearances of the lactating breast.
In the last 20 years imaging modalities have become more sophisticated however research has focused extensively on the abnormal non-lactating breast and little attention has been given to the normal and abnormal lactating breast. Mammography of the lactating breast is limited due to increased glandular tissue and the secretion of breast milk  causing an increase in radio-density that makes the radiographs difficult to interpret . Galactography (the injection of radio-opaque contrast media into the duct orifice at the nipple and subsequent radiography) has illustrated only a portion of the ductal system, and few studies have examined lactating women. This procedure risks the introduction of pathogens into the breast and is therefore inappropriate for investigation of the lactating breast. To date both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) have had little to offer in elucidating pathology in the lactating breast. A recent report using MRI illustrated a duct after its injection with contrast  and another demonstrated dilated ducts and a high proportion of glandular tissue in seven lactating women . However it is likely these modalities may provide much more useful information in the future. In the past, ultrasound investigation of the lactating breast has been limited for the same reasons as mammography; increased density of glandular tissue and the accumulation of milk . More recently, however, malignancies have been confirmed during pregnancy and lactation with both mammography and ultrasound . Ultrasound has undergone enormous technical advances that have improved the resolution of the images dramatically thus allowing imaging of very small structures within the breast. Ultrasound has the added advantage of being non-invasive thus allowing the breast to be examined without distortion. It follows that ultrasound would be the initial modality of choice for investigation of the lactating breast  however this requires a sound knowledge of breast anatomy and pathology and the development of imaging techniques unique to lactation. This paper describes the ultrasound technique used to investigate the anatomy of the lactating breast, current findings as well as breast pathologies associated with lactation.
Gross anatomy of the lactating breast
It is widely believed that the predominant tissue in the lactating breast is glandular. Ultrasound observations made throughout pregnancy show that the proportion of glandular tissue in the breast increases, although at six to twelve weeks adipose tissue was the most prevalent tissue in 20% of women . Using a semi-quantitative ultrasound measurement of the glandular and adipose tissue in lactating Caucasian mothers it was found that there was approximately twice as much glandular tissue as adipose tissue in the lactating breast. However, the proportion of these tissues were highly variable with up to half of the breast comprised of adipose tissue in some women and conversely up to 80% of the breast composed of glandular tissue in others . In addition it was found the amount of fat situated between the glandular tissues was highly variable which has also been observed in the non-lactating breast .
Breast ultrasound requires the highest resolution of almost all imaging procedures. In particular it requires high resolution of the near field (subcutaneous portion of the breast). The appropriate transducer is an electronically focused linear array with a frequency of 7–12 MHz with multiple focal zones to increase resolution of the area of interest . However, in the case of the large lactating breast a 5 MHz probe may be desirable to both increase penetration of the breast and improve focusing at depth. Features that will improve imaging are: continuous electronic focusing, broad bandwidth and short pulse width. More recent developments such as coded harmonics and spatial compounding improve contrast resolution thus providing more detailed images of the structures of the breast.
The time compensation curve (compensates for the normal attenuation of the sound waves in the tissue) ranges between a gentle slope for predominately fatty breasts to a steep slope for dense breasts. The gain setting compensates for attenuation without discriminating for depth thus amplifying all of the returning echoes . Too high a setting will eliminate visualization of small structures and reduce the demarcation between adipose and glandular tissue. Too low a gain setting will result in the fat in the breast being displayed as anechoic (devoid of echoes or very dark/black) rather than hypoechoic (appears a darker shade of gray compared to surrounding tissues). One or two focal zones are used to improve resolution of the image, by narrowing the ultrasound beam, at selected depths of insonation. The power setting should be high enough to ensure adequate visualisation of all the tissues of the breast from the skin to the pectoral muscle [8, 17]. Some ultrasound systems default to low power settings therefore one may need to increase the power before choosing a lower frequency transducer .
When investigating the non-lactating breast for abnormalities the patient is often placed in the posterior oblique position with the breast to be examined raised. The objective of this position is to flatten the breast and bring the internal structures more parallel to the ultrasound beam. Thus the degree of obliquity depends on the size and shape of the breast and may vary during scanning. Upright positions are used occasionally to determine if there is either floating debris or dependent levels within cystic lesions. For the lactating breast it may be necessary to use a combination of oblique and upright positions to adequately examine the entire breast, particularly in women with very large breasts. Warm ultrasonic gel is used for scanning to enhance the transmission of sound through the skin into the breast and maintain good contact [3, 18, 19].
Ultrasound can be targeted to the area of a palpable abnormality in both the non-lactating and lactating breast. Location of the abnormality and simultaneous scanning should elucidate any distortion of the normal structures of the breast. When no abnormality is detected comparison to the opposite breast may be useful. Further investigation should be considered in the absence of ultrasound changes.
The aim of the ultrasound examination of the breast is to survey the entire breast for abnormalities. When an abnormality is detected targeted ultrasound is employed.
However a more radial and flexible approach is required in the lactating breast to interrogate the ductal system as the ducts have proliferated and often display an erratic course. Lobes are indistinguishable due to the intertwining nature of the ducts and lobules. If an abnormality is detected, targeted ultrasound using multiple planes and palpation, if possible should be performed. Labelling of images can be made with annotation (Clock Method) and/or body markers.
S = Subcutaneous fat.
Where GTOT, STOT, ITOT and RTOT represent the sum of all depth measurements for all of the breast tissues made at 30 mm intervals for all 8 radii. Results are expressed as totals of the tissue in millimetres and as a percentage of the total tissue of the breast .
Normal ultrasonic appearances of the breast
The subcutaneous fat appears as a hypoechoic layer of tissue beneath the skin lines. Cooper's ligaments run between the superficial and deep fascia of the breast providing a framework for the parenchyma and appear as echogenic bands running obliquely from the posterior of the breast to the skin. The curved and fibrous nature of the ligaments may reflect the beam causing posterior shadowing. Changing the transducer pressure and angle will either reduce or eliminate this artefact [23, 24]. The superficial fascia of the breast is occasionally seen as another thin echogenic line below the skin .
There is a wide range of ultrasonic patterns of the breast depending on the amount of fat interspersed throughout the glandular tissue. Generally the adipose tissue is hypoechoic with respect to the echogenic glandular tissue but is sometimes isoechoic. Ducts appear as small hypoechoic linear structures that are larger under the areola becoming progressively smaller towards the periphery of the breast . Echogenicity of the duct can vary depending on both the surrounding tissue and the luminal contents . The main ducts are arranged radially and two to three ducts can be identified merging with the main duct. Duct diameters above two to three millimetres are considered enlarged and indicative of ductal ectasia [26, 27] or may be related to mastalgia , however a range of duct diameters from 0.6 to 4.4 mm have been measured in asymptomatic women . Ducts of the non-lactating breast are generally not distorted by compression, unless containing fluid such as blood, and can be distinguished from vessels by the use of Colour Doppler Imaging. Colour Doppler Imaging is useful for suspicious lesions within a duct as they may exhibit vascularity . Normal terminal ductolobular units can be imaged as isoechoic structures (same echogenicity as the fat) shaped like a tennis racquet hence are only visible when surrounded by the more echogenic fibrous tissue  therefore identification is variable. Some authors believe each of the lobes (segments) of the non-lactating breast can be imaged with ultrasound  despite the inability of surgeons to remove a lobe as a distinct entity . Alternatively others refer to the glandular area as the mammary zone . Difficulty discerning lobes is very likely due to their intertwined nature , however, the pattern of glandular tissue is observed more clearly by ultrasound than by mammography . The retromammary fat appears as a hypoechoic layer above the pectoralis muscles that displays a typical fibrillar pattern.
The ultrasonic appearances of the structures of the non-lactating and lactating breast
Structures of the breast
Large breasts often contain a large proportion of adipose tissue
Large breasts often contain a large proportion of adipose tissue
Echogenic walls may be visible
Do not distend
2 mm or less (>2 mm considered ductal ectasia)
Hypoechoic, can contain echogenic flecks representing milk fat globules Echogenic walls may be visible
Distend at milk ejection
Resting state – 2 mm (1–10 mm)
Hyperechoic (1–3 mm)
Thicker in the areolar region
Stromal fibrous tissue
Predominantly hyperechoic – tends to be more echogenic with more milk in the breast
Arteries and veins
Additional File 1: Ultrasound video of milk ejection in the unsuckled breast during a breastfeed. Substantial duct dilation accompanied by milk flow is evident at milk ejection. Milk is flowing towards the right upper corner of the image where the nipple is situated. (MPG 6 MB)
Additional File 2: Ultrasound video of milk ejection in the non-expressed breast during a pumping session. Minimal duct dilation accompanied by obvious milk flow is observed at milk ejection. The nipple is situated in the upper right corner of the image. (MPG 13 MB)
Blood flow to the lactating breast
The majority of the blood is supplied to the breast by two major arteries, the Internal Mammary Artery (IMA) and the Lateral Thoracic Artery (LTA). The IMA supplies the breast via the posterior and anterior medial branches and the Lateral Thoracic Artery supplies the lateral portion of the breast via the lateral mammary branch. Cooper depicted three anterior branches of the IMA, however he found most often that one branch located at the second intercostal space was larger and thus provided more blood to the gland compared to the others . However iterations of Cooper's work has lead to a more extensive arterial network that includes branches of both the intercostal arteries and the thoracoacromial artery .
During pregnancy mammary blood flow increases to double pre-pregnancy levels by 24 weeks and then remains constant during lactation [30, 31]. As with the non-lactating breast Geddes has shown that there is a wide variation between women in the proportion of blood supplied by each artery and there is little evidence of symmetry between breasts . Along with an increase in blood flow, the superficial veins of the breast also become more prominent during pregnancy and lactation .
The 24 hour mammary blood flow required to produce one litre of milk in women is similar to that of other species (500:1). Currently no relationship between blood flow and milk production has been demonstrated in women. However, within a mother mammary blood flow is markedly reduced in a gland that is synthesising little milk compared to one producing a normal volume of milk. For example, in cases of unilateral hypoplasia and obstruction of milk flow due to nipple piercing mean blood flow velocities of the IMA and LTA have been shown to be reduced by half to two-thirds compared to the breast producing copious amounts of milk .
Doppler ultrasound of the lactating breast
Many attempts have been made to determine if Colour Doppler Imaging can differentiate between benign and malignant masses with more accuracy than B-mode imaging alone. Results have been conflicting mainly due to many benign lesions exhibiting some vascularity .
Ultrasound Doppler technique
Normal ultrasonic appearances and blood flow parameters
The arteries and veins of the breast can be visualized and assessed with Colour Doppler ultrasound. In addition veins are occasionally imaged as anechoic tubular structures that compress with gentle pressure. During breastfeeding blood flow decreases by 40–50% just prior to milk ejection and then increases in the following one to two minutes . Spontaneous milk ejections can occur during scanning which may affect Doppler measurements. Common signs of milk ejection are leaking of milk from the nipple, sensations in the breast of pins and needles, pain pressure and sometimes maternal feelings of warmth and nausea [29, 37].
Doppler blood flow parameters for the mammary branches of the Internal Mammary Artery Branch (IMA) and Lateral Thoracic Artery (LTA) for both the non-lactating and lactating breast
Mean blood flow parameters
IMA Diameter (mm)
Systolic velocity (cm/s)
Diastolic velocity (cm/s)
Mean velocity (cm/s)
Flow volume (mL/min)
LTA Diameter (mm)
Systolic velocity (cm/s)
Diastolic velocity (cm/s)
Mean velocity (cm/s)
Flow volume (mL/min)
2.2 (2) 
24 hour mammary blood flow (L)
TMAX = Time average maximum velocity
Area = πR2
Lymphatics of the breast
The lymph in the breast is drained by two main pathways; to the axillary  and internal mammary nodes [38, 39]. The axillary nodes have been reported to receive more than 75% of the lymph from both the medial and lateral portions of the breast , whereas, the internal mammary nodes receive lymph from the deep portion of the breast . Nevertheless there is a wide variation in the drainage of lymph from the breast and less common pathways have been demonstrated. Lymph may occasionally pass through either the interpectoral nodes  or lymph nodes in the breast parenchyma . Sometimes direct drainage of lymph occurs to the supraclavicular nodes  and infrequently lymph may pass retrosternally into the contralateral internal mammary nodes. In addition lymph has been shown to drain into the posterior and anterior intercostal nodes .
Normal appearances of the lymphatics of the breast
There has been little investigation of the lymphatic drainage of the lactating breast despite its importance in clinical conditions such as engorgement and mastitis.
Mammary nerves and normal lymphatics are not visualised on ultrasound, however when the lymphatics are dilated due to either inflammation or malignant invasion they become visible as very thin anechoic/hypoechoic lines running parallel and perpendicular to the skin in the subcutaneous tissues . Lymph nodes are demonstrated in the breast and axilla as well defined oval masses with an echogenic hilum and hypoechoic cortex .
Pathology of the lactating breast
Ultrasonic characteristics of common pathologies of the lactating breast
Margins – well circumscribed with thin smooth walls
No internal vascularity
Margins – well defined or occasionally ill-defined
Echogenicity – homogenous to heterogenous
No posterior enhancement unless internal calcification is present
Margins – wide, indistinct, hypoechoic
Echogenicity – predominantly echo-free to heterogenous
No internal vascularity
Margins – irregular and ill-defined
Echogenicity – heterogenous echogenicity
+/- posterior shadowing
Acute – anechoic and simple or mainly anechoic with some diffuse echoes and multiloculated.
Sub-acute – contain echoes of mild to moderate intensity
Chronic – diffuse echogenicity ranging from moderate to highly echogenic
Can be simple, multilocular and heterogenous
Possible fat-fluid level
Movement of the contents can be demonstrated by compression with the transducer
Galactoceles are centrally devoid of blood vessels however flow may be demonstrated in the walls – use of colour Doppler can confirm this
Focal – similar appearances to an acute galactocele, non-compressible.
Diffuse – often an area of increased echogenicity associated with a palpable solid region. Occasionally a hypoechoic rim surrounds a more echogenic central region
Margins – well circumscribed to ill-defined
Echogenicity – hypo-, hyper or isoechoic
Homo- or heterogenous
Posterior enhancement or acoustic shadowing
+/- internal vascularity
Increased echogenicity of the glandular tissue due to the large volume of milk in the breast.
Severe engorgement may exhibit ultrasonic signs similar to mastitis (see below)
Early/acute phase: there may be no discernable ultrasonic changes in echogenicity breast tissues
Skin – thickens and becomes more hyperechoic
Cooper's ligaments and stromal fibrous tissue decrease in echogenicity
Areas of inflammation frequently have increased blood flow
Advanced stages: Skin thickening is prominent
Distinction between different breast tissues disappears
Breast thickness increases
Galactoceles are dilated terminal ducts (ductules) comprised of a layer of epithelium and a layer of myoepithelium and are filled with milk. Their cause is thought to be the result of an obstruction of a milk duct by either a lesion or inflammation . The echogenicity of the galactocele is dependent upon its stage as the protein in the milk denatures and fat emulsifies over time. Galactoceles tend to have well-defined, thin echogenic walls but may also present with an anechoic fluid rim. The internal echogenicity however varies from homogeneous mid-level echoes to heterogeneous echogenicity with or without accompanying fluid levels. Distal enhancement is present due to lack of acoustic attenuation provided by the milk. Echogenic areas with acoustic shadowing are believed to be inspissated contents . Their shape may also depend upon the location in the breast. Aspiration under ultrasound guidance is diagnostic and therapeutic in cases of large galactoceles .
Abscesses reportedly occur as a complication of approximately three percent of mastitis cases in developed countries  and vary in their ultrasonic presentation. The margins of the abscess are often wide, indistinct and hypoechoic compared to surrounding tissues. The centre is fluid filled and the echogenicity ranges from hypoechoic to mixed echogenicity. Occasionally layers are visible within the abscess. Posterior enhancement is evident due to the fluid filled nature of the abscess and it will have limited compressibility . Colour Doppler ultrasound imaging may assist with demonstrating internal blood flow in inflamed hypoechoic tissue thus ruling out an abscess . Abscesses may be drained under ultrasound guidance however, follow up to ensure complete resolution is recommended in these cases [53–55]. More recently vacuum assisted drainage has shown to be successful in lactating women with recurrent abscesses . Alternatively abscesses can be incised and drained surgically. Cessation of breastfeeding is not necessary during any of the treatments .
Lactating adenomas are a relatively uncommon breast tumour that is often first recognized during either pregnancy or lactation. They develop from the inner most layer of alveoli which is comprised of lactocytes (secretory epithelium) . Since there are a wide variety of ultrasonic appearances that include benign and malignant features a large core needle biopsy (LCNB) is often performed to obtain a diagnosis. LCNB is preferred to fine needle aspiration to reduce the possibility of false-positive diagnoses of malignancy. Many adenomas resolve after weaning however some women opt to have them surgically removed [44, 59].
The incidence of breast cancer in pregnant and lactating women varies from 1 in 3000 to 1 in 10000 women [60, 61]. Symptoms often begin before or during pregnancy . Unfortunately these cancers are often at an advanced stage as diagnosis is frequently delayed. In addition the increased mammary blood flow during pregnancy and lactation may accelerate the growth of the tumour . The sensitivity of mammography is reduced due to the increased amount of glandular tissue and water content of the breast resulting in increased parenchymal density of the radiographs. However, ultrasound has been shown to be accurate in pregnant and lactating women with a focal mass .
Breast cancers in pregnant and lactating women exhibit the same typical features as would be expected in the non-lactating woman – a focal mass of heterogeneous or low echogenicity with irregular margins. Additional features such as posterior shadowing may or may not be present. In addition the axillary lymph nodes should be scanned to exclude metastases.
A rapid increase in milk production occurs at secretory activation around day two to five postpartum . Breasts can become quite tense and full at this stage. Symptoms resolve with frequent feeding and/or effective emptying of milk from the breast. Cold compresses may also assist in relief of the symptoms. Severe engorgement may lead to compromised milk supply, nipple trauma and mastitis . Ultrasound appearances include an increase in echogenicity of the glandular tissue due to the large volume of milk in the breast. In addition the breasts are often tense and painful. Severe engorgement may exhibit ultrasonic signs similar to mastitis such as skin thickening and increased vascularity.
Mastitis is an inflammation of the breast and has been classified into two types: infectious and non-infectious. Non-infective mastitis can occur as a result of blocked ducts, engorgement or physical injury to the breast resulting in a localized inflammatory response . Infective mastitis is a result of invasion of the breast by a pathogen most commonly Staphylococcus aureus however other species such as β-haemolytic streptococci, Streptococcus faecalis and Escherichia coli have been identified as causative organisms. The most common passage of entry is considered to be via nipple fissure due to trauma . Indeed this is feasible considering retrograde milk flow is noted within the milk ducts during the latter half of milk ejection in the breast that is not fed or pumped from [14, 66, 67].
Ultrasound imaging is the most appropriate initial investigation of the pathological lactating breast. However the mammary anatomy, increased density of glandular tissue, compressibility of milk ducts, raised mammary blood flow and the changes in mammary physiology associated with lactation should be taken into consideration when refining breast ultrasound scanning techniques. Furthermore knowledge of lactation-associated pathology will ensure more accurate diagnoses and treatment for lactating women.
I would like to thank the mothers and infants who participated in the studies that contributed to this manuscript and Professor Peter Hartmann for his critical revision of the intellectual content of this manuscript.
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