Table 2 Side effects reported by women using domperidone according to the maximum dose used and whether treatment was ceased due to side effects
Maximum Reported Dose | Ceased due to side effects* | ||||||
|---|---|---|---|---|---|---|---|
≤ 30 mg/day; N = 178 | 31 – 60 mg/day; N = 155 | ≥ 61 mg/day; N = 22 | Yes; N = 31 | No; N = 141 | |||
n (%) | n (%) | n (%) | P-value | n (%) | n (%) | P—value | |
Any | 74 (42) | 82 (53) | 16 (73) | 0.004 | 31 (100) | 141 (100) | < 0.001 |
Two or more | 34 (19) | 36 (23) | 10 (45) | 0.626 | 21 (68) | 59 (42) | 0.014 |
Weight gain | 33 (19) | 42 (27) | 13 (59) | < 0.001 | 15 (48) | 73 (52) | 0.004 |
Headache | 25 (14) | 29 (19) | 5 (23) | 0.370 | 18 (58) | 41 (29) | < 0.001 |
Dry mouth | 18 (10) | 24 (15) | 5 (23) | 0.133 | 9 (29) | 38 (27) | 0.012 |
Fatigue | 12 (7) | 18 (12) | 1 (5) | 0.272 | 7 (23) | 24 (17) | 0.011 |
Depression | 9 (5) | 7 (5) | 4 (18) | 0.054 | 6 (19) | 14 (10) | 0.004 |
Irritability | 7 (4) | 11 (7) | 4 (18) | 0.030 | 7 (23) | 15 (11) | 0.001 |
Nausea | 8 (4) | 4 (3) | 1 (5) | 0.509 | 2 (6) | 11 (8) | 0.316 |
Stomach cramps | 7 (4) | 6 (4) | 1 (5) | 1.000 | 5 (16) | 9 (6) | 0.004 |
Other | 6 (3) | 4 (3) | 2 (9) | 0.212 | 4 (13) | 8 (6) | 0.014 |
Heart palpitations /racing heart | 4 (2) | 7 (5) | 2 (9) | 0.140 | 6 (19) | 7 (5) | < 0.001 |
Dizziness /fainting | 3 (2) | 7 (5) | 2 (9) | 0.075 | 3 (10) | 9 (6) | 0.077 |
Involuntary movements /jerking | 3 (2) | 1 (1) | 0 (0) | 0.711 | 1 (3) | 3 (2) | 0.307 |
Skin rash | 1 (1) | 1 (1) | 0 (0) | 1.000 | 2 (6) | 0 (0) | 0.007 |