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Table 1 Demographic and baseline characteristics in infants

From: Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial

Demographics

OAC group (N = 127)

Control group (N = 125)

t/x2-value

df

P-value

Relative risk/Mean difference (95% CI)

Sex (male), n (%)

65 (51.18)

78 (62.40)

3.23

1

0.07

0.82 (0.66, 1.02)

Gestational age (weeks), mean ± SD

30.00 ± 1.83

29.65 ± 2.04

1.45

250

0.15

2.48 (−0.89, 5.85)

Birthweight(g), mean ± SD

1, 302.26 ± 209.81

1, 328.72 ± 222.17

−0.97

250

0.33

− 26.46 (−80.07, 27.15)

Small for gestational age, n (%)

22 (17.32)

18 (14.40)

0.40

1

0.53

1.20 (0.68, 2.13)

Extremely low birthweight infant, n (%)

14 (11.02)

11 (8.80)

0.35

1

0.56

1.25 (0.59, 2.65)

Sicker infants, n (%)

20 (15.75)

22 (17.60)

0.16

1

0.69

0.90 (0.52, 1.56)

Birth head circumference (cm), mean ± SD

27.16 ± 1.50

27.08 ± 1.78

0.42

250

0.68

0.09 (−0.32, 0.50)

Apgar score at 5 min, median (IQR)

9 (9-10)

9 (9-10)

7, 646.00

-a

0.40

-b

TRIPS score, median (IQR)

13 (8-13)

13 (8-13)

8, 848.00

-a

0.06

-b

NRDS, n (%)

39 (30.71)

30 (24.00)

1.43

1

0.23

1.28 (0.85, 1.92)

Pulmonary surfactant use, n (%)

37 (29.13)

30 (24.00)

0.85

1

0.36

1.21 (0.80, 1.84)

Time to start OAC/NS (h), mean ± SD

24.47 ± 11.16

23.78 ± 10.92

0.50

250

0.62

0.70 (−2.04, 3.44)

Established enteral feeding within 24 h after birth, n (%)

111 (87.40)

105 (84.00)

0.60

1

0.44

1.04 (0.94, 1.15)

Maternal age (y), mean ± SD

31.81 ± 4.51

31.83 ± 4.79

−0.03

250

0.98

−0.02 (−1.17, 1.14)

Gestational hypertension, n (%)

23 (18.11)

15 (12.00)

1.84

1

0.18

1.51 (0.83, 2.76)

Gestational diabetes mellitus, n (%)

42 (33.07)

34 (27.20)

1.03

1

0.31

1.22 (0.83, 1.78)

Antenatal steroid use, n (%)

115 (90.55)

115 (92.00)

0.17

1

0.68

0.98 (0.91, 1.06)

Antenatal magnesium sulfate use, n (%)

82 (64.57)

68 (54.40)

2.70

1

0.10

1.19 (0.97, 1.46)

Twin or multiple gestation, n (%)

48 (37.80)

42 (33.60)

0.48

1

0.49

1.13 (0.81, 1.57)

Cesarean delivery, n (%)

77 (60.63)

71 (56.80)

0.38

1

0.54

1.07 (0.87, 1.31)

Premature rupture of membranes, n (%)

50 (39.37)

60 (48.00)

1.91

1

0.17

0.82 (0.62, 1.09)

Histologic chorioamnionitis, n (%)

42 (33.07)

33 (26.40)

1.34

1

0.25

1.25 (0.85, 1.84)

  1. TRIPS transport risk index of physiologic stability, NRDS neonatal respiratory distress syndrome, OAC oropharyngeal administration of colostrum, IQR interquartile range, SD standard deviation. Sicker infants were defined as infants whose mechanical ventilation was started within the first 3 postnatal days and continued for at least 3 days or until death
  2. a Nonparametric test: df cannot be calculated
  3. b Nonparametric test: mean difference and its 95% CI cannot be calculated