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Table 1 Baseline characteristics and clinical outcomes in neonates who received BMCFs and the control group

From: Administration of breast milk cell fractions to neonates with birthweight equal to or less than 1800 g: a randomized controlled trial

Characteristic*

Total (N = 156)

Received BMCFs (N = 75)

Control (N = 81)

OR (95% CI)‡

Df ‡

P †

Gestational age (week)

30.79 ± 2.47

31.00 ± 2.61

30.59 ± 2.34

 

151

0.18

Birthweight (grams)

1390.1 ± 314.4

1392.0 ± 325.6

1388.3 ± 305.7

 

154

0.85

Sex

 Female

69 (44.2%)

34 (45.3%)

35 (43.2%)

1.09 (0.58, 2.05)

 

0.79

 Male

87 (55.8%)

41 (54.7%)

46 (56.8%)

 

Delivery mode

 NVD

33 (21.2%)

10 (13.3%)

23 (28.4%)

2.58 (1.13, 5.87)

 

0.02

 C-Section

123 (78.8%)

65 (86.7%)

58 (71.6%)

 

 1-min Apgar

8.0 [6.0–8.0]

9.0 [8.0–10.0]

9.0 [8.0–9.0]

 

154

0.53

 5-min Apgar

9.0 [8.0–9.75]

9.0 [8.0–10.0]

9.0 [8.0–9.0]

 

154

0.42

 Gravidity

2.0 [1.0–3.0]

2.0 [1.0–3.0]

2.0 [1.0–3.0]

 

154

0.91

 Parity

1.0 [1.0–2.0]

1.0 [1.0–2.0]

1.0 [1.0–2.0]

 

154

0.52

Use of infant formula

 Formula milk consumption

20 (12.8%)

6 (8.0%)

14 (17.3%)

0.42 (0.15, 1.15)

 

0.08

 Formula milk consumption duration (day)

17.4 ± 12.7

14.8 ± 11.4

18.5 ± 13.4

 

18

0.57

In-hospital outcomes

 Hospital length of stay (day)

28.0 ± 22.9

29.8 ± 23.8

26.3 ± 21.9

 

154

0.48

 Discharge weight (grams)

1694.6 ± 212.6

1679.1 ± 195.2

1710.8 ± 229.7

 

135

0.60

 Mortality

19 (12.2%)

5 (6.7%)

14 (17.3%)

0.34 (0.12, 1.00)

 

0.04

 Intubation period (day)

3.6 ± 6.9

3.2 ± 7.1

4.0 ± 6.6

 

152

0.17

 NIV period (day)

8.1 ± 10.9

9.4 ± 11.9

6.9 ± 9.7

 

153

0.21

 NEC

11 (7.1%)

4 (5.3%)

7 (8.8%)

0.59 (0.16, 2.09)

 

0.41

 BPD

24 (15.4%)

14 (18.7%)

10 (12.3%)

1.63 (0.67, 3.93)

 

0.27

 ROP

41 (26.3%)

21 (28.4%)

20 (24.7%)

1.21 (0.59, 2.47)

 

0.60

 Positive blood culture

10 (6.4%)

4 (5.4%)

6 (7.6%)

0.69 (0.19, 2.57)

 

0.58

  1. * Data are presented as mean ± standard deviation, number (%), or median [interquartile range]
  2. † Statistically significant P-values are bolded. Categorical variables were compared using the chi-square test and numerical variables were compared using the Mann–Whitney U-test
  3. ‡ Odds ratio (OR) and 95% confidence interval (95% CI) are presented for categorical variables, and the degree of freedom (df) is presented for numerical variables
  4. BMCFs breast milk cell fractions, BPD bronchopulmonary dysplasia, C-Section Cesarean section, DF degree of freedom, NEC necrotizing enterocolitis, NIV non-invasive ventilation, NVD normal vaginal delivery, OR odds ratio, ROP retinopathy of prematurity