Duration of breastfeeding, age at introduction of complementary foods and allergy-related diseases: a prospective cohort study

Table 7 Association between breastfeeding duration and allergy-related disease in recent meta-analyses [6, 7]

Condition & age	Comparison for breastfeeding duration^a	All studies included		Prospective cohort studies		Ref
Condition & age	Comparison for breastfeeding duration^a	N^b	OR	N	OR	Ref
Wheeze
0–4 yo	TBF > 5-7mo vs. < 5-7mo	9	0.90 (0.72, 1.12)	6	0.89 (0.65, 1.21)	[6]
5–14 yo	TBF > 5-7mo vs. < 5-7mo	2	0.86 (0.70, 1.06)	1	0.88 (0.71, 1.09)	[6]
Recurrent wheeze
0–4 yo	TBF > 5-7mo vs. < 5-7mo	6	0.79 (0.61, 1.04)	3	0.73 (0.56, 0.96)	[6]
5–14 yo	TBF > 5-7mo vs. < 5-7mo	9	0.76 (0.62, 0.92)	4	0.82 (0.66, 1.03)	[6]
Asthma^c
5–18 yo	More vs. Less	29	0.90 (0.84, 0.97)	13	0.94 (0.80, 1.11)	[7]
Allergic rhinitis / rhinoconjunctivitis
0–4 yo	TBF > 5-7mo vs. < 5-7mo	2	0.81 (0.64, 1.02)	--- ^d		[6]
0–5 yo	More vs. Less	6	0.79 (0.63, 0.98)	2	0.91 (0.74, 1.13)	[7]
5–14 yo	TBF > 5-7mo vs. < 5-7mo	1	1.14 (0.75, 1.72)	--- ^d		[6]
5–18 yo	More vs. Less	9	1.05 (0.99, 1.12)	4	1.12 (1.02, 1.24)	[7]
Ezcema
0–2 yo	More vs. Less	16	0.95 (0.85, 1.07)	15	0.97 (0.86, 1.10)	[7]
0–4 yo	TBF > 5-7mo vs. < 5-7mo	4	0.93 (0.80, 1.07)	3	0.97 (0.75, 1.12)	[6]
2–18 yo	More vs. Less	20	1.09 (0.99, 1.20)	6	1.36 (0.90, 2.06)	[7]
5–14 yo	TBF > 5-7mo vs. < 5-7mo	2	1.35 (1.07, 1.72)	--- ^d		[6]

TBF Total (any) breastfeeding
^aBoth meta-analyses report several comparisons based of different definitions of breastfeeding duration and exclusivity, here summarise the results from the comparison which would have included our own categorisation of breastfeeding duration. Meta-analysis by Lodge et al. [7] included a wide variety of studies comparing “more” vs “less” breastfeeding, whilst Garcia-Larsen et al. [6] completed separate meta-analyses for more specific comparisons of breastfeeding duration
^bNumber of studies in the meta-analysis
^cLodge et al. include parental reports of wheeze as “asthma” in their meta-analysis
^dOnly prospective cohort studies available for inclusion in these analyses

ISSN: 1746-4358