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Table 3 The interrelation between Sirtuin3, 8-hydroxy-2-deoxyguanosine, brain-derived neurotrophic factor and serotonin in early breast milk of mothers giving birth at term vaginally or by Caesarean section and those delivering preterm (Spearman’s rank correlation)

From: Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study

  Vaginal birth at term Caesarean section at term Preterm birth
SIRT3 8-OHdG BDNF 5-HT SIRT3 8-OHdG BDNF 5-HT SIRT3 8-OHdG BDNF 5-HT
Biomarkers in breast milk
 SIRT3 R   0.41* −0.20 0.48*   0.50** 0.05 0.40*   0.40* −0.20 0.54**
p   0.04 0.34 0.01   0.006 0.81 0.03   0.03 0.26 0.001
 8-OHdG R 0.41*   −0.29 0.78** 0.50**   −0.08 0.43* 0.40*   −0.26 0.40*
p 0.04   0.16 0.000 0.01   0.67 0.02 0.03   0.15 0.02
 BDNF R −0.20 −0.29   −0.34 0.05 −0.08   −0.17 − 0.20 − 0.26   − 0.26
p 0.34 0.16   0.09 0.81 0.67   0.37 0.26 0.15   0.15
 5HT R 0.48* 0.78** −0.34   0.40* 0.43* −0.17   0.54** 0.40* −0.26  
p 0.01 0.000 0.09   0.03 0.02 0.37   0.001 0.02 0.15  
  1. SIRT3 Sirtuin 3, 8-OHdG 8-hydroxy-2′-deoxyquanosine, BDNF Brain-derived neurotrophic factor, 5-HT Serotonin
  2. **= p < 0.01, *= p < 0.05