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Table 2 Cord blood and early breast milk levels of Sirtuin3 (Sirt3), 8-hydroxy-2-deoxyguanosine (8OHdG), brain-derived neurotrophic factor (BDNF) and serotonin (5HT) of mothers giving birth at term vaginally or by Caesarean section and those delivering preterm (median with 25th and 75th centiles)

From: Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study

  SIRT 3 (ng/ml) 8-OHdG (pg/ml) BDNF (ng/ml) 5-HT (ng/ml) Compared Groups
I. Venous cord blood   p = 0.001**
X2 = 13.61 		  p < 0.001**
X2 = 21.82 		  p < 0.001**
X2 = 38.55 		  p = 0.09
X2 = 4.91 		1–2-3
 1. Vaginal birth at term (N = 27) 0.27 (0.23;034) p = 0.224
Z = -1.22 		7.42 (0.05;14.41) p = 0.54
Z = -0.61 		77.94 (64.03;119.09) p = 0.007**
Z = -2.72 		90.96 (55.53;110.64) p = 0.57
Z = -0.57 		1–2
 2. Caesarean section at term (N = 29) 0.24 (0.18;0.31) p = 0.02*
Z = -2.41 		8.41 (1.34,15.48) p < 0.001**
Z = -3.68 		57.22 (54.76;76.80) p < 0.001**
Z = -4.68 		73.55 (56.59;107.29) p = 0.10
Z = -0.1.64 		2–3
 3. Preterm birth (N = 28) 0.20 (0.15;0.24) p < 0.001**
Z = -3.62 		21.10 (11.63;26.87) p < 0.001**
Z = -4.28 		36.22 (24.83;47.17) p < 0.001**
Z = -5.40 		58.39 (45.52;90.70) p = 0.04*
Z = -2.07 		1–3
II. Breast milk   p = 0.184
X2 = 3.39 		  p = 0.01**
X2 = 9.55 		  p = 0.03*
X2 = 7.23 		  p = 0.02*
X2 = 8.03 		1–2-3
 1. Vaginal birth at term (N = 27) 0.34 (0.17;1.27) p = 0.06
Z = -1.94 		13.29 (4.15;30.45) p = 0.09
Z = -1.68 		0.97 (0.76;1.11) p = 0.68
Z = -0.42 		14.69 (6.13;24.10) p = 0.48
Z = -0.70 		1–2
 2. Caesarean section at term (N = 29) 1.72 (0.26;5.25) p = 0.80
Z = -0.25 		7.76 (3.20;17.6) p = 0.002**
Z = -3.11 		0.24 (0.20;0.94) p = 0.02*
Z = -2.39 		8.65 (3.43;23.35) p = 0.01*
Z = -2.50 		2–3
 3. Preterm birth (N = 28) 2.19 (0.23;5.77) p = 0.22
Z = -1.23 		15.30 (10.85;35.97) p = 0.24
Z = -1.17 		0.03 (0.02;0.11) p = 0.008**
Z = -2.65 		25.82 (11.04;34.72) p = 0.02*
Z = -2.25 		1–3
I-II. Cord blood and breast milk
 1. Vaginal birth at term (N = 27)   p = 0.08
Z = -1.75 		  p = 0.01*
Z = -2.46 		  p = 0.03*
Z = -2.20 		  p < 0.001**
Z = -4.37 		 
 2. Caesarean section at term (N = 29)   p < 0.001**
Z = -3.80 		  p = 0.61
Z = -0.51 		  p = 0.02*
Z = -2.37 		  p < 0.001**
Z = -4.76 		 
 3. Preterm birth (N = 28)   p < 0.001**
Z = -4.00 		  p = 0.70
Z = -0.38 		  p < 0.001**
Z = -4.78 		  p < 0.001**
Z = -4.74 		 
  1. Comparisons between three groups (1,2,3) by Kruskal-Wallis test, between two groups (1–2 or 2–3 or 1–3) by Mann-Whitney U test and between venous cord blood and breast milk (I-II.) were done by Wilcoxon test
  2. **= p < 0.01, *= p < 0.05
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International Breastfeeding Journal

ISSN: 1746-4358