Table 2 Impact of maternal medicines on breastfeeding
From: Postpartum women’s use of medicines and breastfeeding practices: a systematic review
Author and publication year | Country, study type, sample, design and settings | Results | Quality score and limitation(s) |
|---|---|---|---|
Chaves et al., 2011 [33] | Brazil, cohort study, n = 246 | Duration of breastfeeding was longer in women who used no medicine or who used medicines compatible with breastfeeding (p < 0.05). | Macfarlane’s checklist: See Table 1 |
Other information is available in Table 1. | Newcastle-Ottawa: 8/9 (Selection: 4*, Comparability:2*, Outcome: 2*) | ||
Limitation(s): See Table 1 | |||
Lee et al., 2000 [43] | Canada, cohort study, n = 36 (exposure group) | 44 % of women receiving PTU initiated breastfeeding compared to 83 % in the two control groups (Group 1 vs Group 2, p < 0.01; group 1 vs group 3, p < 0.01). | Macfarlane’s checklist: Abstract: 88 %, Paper: 73 % |
Women requiring propylthiouracil (PTU) during pregnancy (Jan 1990 to Sept 1997) were recruited and interviewed postpartum regarding their choice of infant feeding method. 36 women required PTU postpartum (Group 1); 30 did not (Group 2); 36 healthy women were controls (Group 3). | Newcastle-Ottawa: 8/9 (Selection: 4*, Comparability: 2*, Outcome: 2*) | ||
Limitation(s): Study is based on selective medicine | |||
Ito, 1999 [47] | Canada, cohort study, n = 88 | 69 women used medicines (Group 1) and 19 women did not start the medicine of concern (Group 2). 22 (32 %) of Group 1 women stopped breastfeeding before the infant was 6 months old while 1 (5 %) of the Group 2 women did so (p < 0.04). | Macfarlane’s checklist: Abstract: 88 %, Paper: 82 % |
Breastfeeding women who received reassuring advice about compatibility of medicine from the Motherisk Teratogen Information Center in Toronto about their medicines in 1993 were followed up by interview up to cessation of breastfeeding or until the infant reached to 7 months. | Newcastle-Ottawa: 7/9 (Selection: 4*, Comparability: 1*Outcome: 2*) | ||
Limitation(s): Small sample size | |||
Ito et al., 1995 [48] | Canada, cohort study, n = 34 (exposure group) | 50 % of women receiving medicines started breastfeeding compared to 85 % in control group (p = 0.004). Median duration of breastfeeding in medicine group was significantly shorter than that in control group (4.7 ± 2.6 vs 9.3 ± 5.7 months, p < 0.005). 65 % of women (11/17) taking antiepileptics stopped breastfeeding within 6 months whereas in control group, only 21 % of women (6/29) did so (p < 0.008). | Macfarlane’s checklist: Abstract: 88 %, Paper: 86 % |
Women receiving antiepileptics during pregnancy were interviewed between April and June, 1993, by the Motherisk Teratogen Information Center in Toronto. 34 pregnant age-matched women were controls. | Newcastle-Ottawa: 7/9 (Selection: 4*, Comparability: 1*, Outcome: 2*) | ||
Limitation(s): Study is based on selective medicine | |||
Ito et al., 1993 [51] | Canada, prospective cohort study, n = 203 | 125 women were followed within 32 weeks of the initial consultation. 106 women started antibiotic therapy and 7 % of them stopped breastfeeding during therapy. | Macfarlane’s checklist: Abstract: 100 %, Paper: 64 % |
Breastfeeding women who consulted the Motherisk Teratogen Information Center in Toronto between Jan 1990 and Jul 1991 about the compatability of antibiotics with breastfeeding after receiving antibiotic prescriptions. | Newcastle-Ottawa: 6/9 (Selection: 4*, Comparability: 1*, Outcome: 1*) | ||
Limitation(s): Study is based on selective medicine, small sample and has attrition bias |